科研平台

何苗，1981年生，研究员，硕士生导师，中心实验室副主任。2009年7月毕业于四川大学生命科学学院（四川大学本科、四川大学硕博连读），理学博士。2009年至今在中国医学科学院输血研究所工作。

主要从事输血传播病原体分子流行病学研究，新发再发病原体的鉴定、系统发育与群体遗传研究；基于新一代测序技术的血液宏基因组学、病毒/噬菌体组学与微生物基因组生物信息学等相关研究。研究结果已在Transfusion Medicine Review、Transfusion、Journal of Medical Virology、One Health、BMC Genomics等国际杂志上发表SCI论文30多篇，引用500余次。

 社会任职及荣誉（含获奖）

四川省科技伦理委员会医学分委会委员，《中国输血杂志》编委。

承担科研项目情况（代表性项目，省部级以上）

（1）国家自然科学基金青年项目，献血/浆人群中人细小病毒B19的亲缘地理学与群体遗传学研究，2014.01-2016.12（牵头）。

（2）国家自然科学基金面上项目，HBV、HCV与HIV在重庆地区的遗传多样性、亲缘地理学与群体遗传学研究，2016.01-2019.12（参与）。

（3）国家重点研发计划课题，输血传播病毒性肝炎转化医学及精准治疗策略研究，2019/08-2022/07（参与）。

（4）国家重点研发计划课题，大动物胚胎发育过程中基因组调控特征，2024/12-2029/11（参与）。

（5）四川省科技厅，应用基础研究计划，基于深度测序方法检测血液传播新发病原体，2015/01-2016/12（牵头）。

（6）四川省科技厅，重点研发项目，基于宏基因组和培养组深度测序方法建立的导致感染性不明原因发热病原体的鉴定和用药指导研究，2019/01-2021/01（牵头）。

（7）四川省科技厅，自然科学基金（面上）项目，血液“暗物质”及血液微生物生态系统的组成与人体“未病”状态的血液检测新指标研究，2024/01-2025/12（牵头）。

代表论著

代表性论文（只选有代表性的）

1.Qiqi Wang, Mengyi Zhao, Anqing Liu, Yuwei Zhao, Yang Huang, Zhan Gao*, Miao He* Investigation of co-existing bacteria in platelets by employing long-term culturomics and metagenomics. Front. Cell. Infect. Microbiol. 15:1607554.doi: 10.3389/fcimb.2025.1607554. (Correspondence)

2.Yuhui Li, Xinhui Zhang, Yang Huang, Lei Gao, Zhan Gao, Miao He* The prevalence of Human Immunodeficiency Virus infection among voluntary blood donors in mainland China: A systematic review and meta-analysis. J Med Virol. 2024 Apr; 96(4):e29599. (Correspondence)

3.Zhao Mengyi, Li Yuhui, Gao Zhan, Liu Anqing, Li Yujia, Li Shilin, Gao Lei, Lan Yue, Huang Mei, Wan Jianhua, He Weilan, Mao Wei, Cai Jie, Zhou Jingyu, Yin Yijing, Guo Yanli, Zhong Qiulei, Huang Yang, Chen Limin, Fan Zhenxin*, He Miao* Plasma metagenomics reveals regional variations of emerging and re-emerging pathogens in Chinese blood donors with an emphasis on human parvovirus B19. One Health 17 (2023) 100602. https://doi.org/10.1016/j.onehlt.2023.100602 (Correspondence)

4.Zhan Gao, Lisong Yu, Ling Cao, Meng Yang, Yuhui Li, Yue Lan, Ruixiang Tang, Yang Huang, Guangxin Luan, Yingfen Liu, Hailin Yu, Ling Jian, Yi Zha, Zhenxin Fan, Yujiao Bai, Mei Luo*, Miao He* and Shanshan Deng*, Analysis of coexisting pathogens in nasopharyngeal swabs from COVID-19. Front. Cell. Infect. Microbiol., 22:13:1140548., https://doi.org/10.3389/fcimb.2023.1140548 (Correspondence)

5.Xu Liu, Xuyuan Liu, Xinqi Wang, Ke Shang, Jiawei Li, Yue Lan, Jiao Wang, Jing Li, Bisong Yue, Miao He* and Zhenxin Fan* (2023) Multi‑omics analysis reveals changes in tryptophan and cholesterol metabolism before and after sexual maturation in captive macaques. BMC Genomics, 24:308. (Correspondence)

6.Qiaoling Zhou, Anqing Liu, Shaoli Wang, Jian Li, Miao He*, Limin Chen*, (2022) Hepatitis C virus screening reactive among blood donors in mainland China: A systematic review and meta-analysis. Transfusion Medicine. 2023 Apr;33(2):147-158. doi: 10.1111/tme.12935. (Correspondence)

7.Mengyi Zhao, Ruiming Yue, Xiaoxiao Wu, Zhan Gao, Miao He* and Lingai Pan* (2022) The diagnostic value of metagenomic next-generation sequencing for identifying Pneumocystis jirovecii infection in non-HIV immunocompromised patients. Front. Cell. Infect. Microbiol.12:1026739.doi: 10.3389/fcimb.2022.1026739 (Correspondence)  

8.Liu Anqing, Liu Xiaojin, Lu Yunwei, Gao Zhan, Tang Ruixiang, Huang Yang, Zheng Liheng, Fan Zhenxin, He Miao* (2022) Two chronically misdiagnosed patients infected with Nocardia cyriacigeorgica accurately diagnosed by whole genome resequencing. Front. Cell. Infect. Microbiol., 12:1032669. (Correspondence)  

9.Chao Liu, Bin Tang, Can Gao, Jianjun Deng, Min Shen, Chaolin Li, Zekun Fu, Zhan Gao, Qi Jiang, Hao Shi, Miao He*, Huaiwu Jiang* and Xu Jia (2021) Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China. Front. Med. 8:783646. (Correspondence)

10.Lingjie Song, Guibao Xiao, Ruixiang Tang, Xianqin Zhang, Zhan Gao, Shixia Sun, Lin Zhang, Youjun Feng, Guangxin Luan, Sheng Lin*, Miao He* and Xu Jia* (2021) Next-generation sequencing and RT-PCR to identify a 32-day SARS-CoV-2 carrier. Clin Chem Lab Med. 19;59(6):e251-e254. doi.org/10.1515/cclm-2020-1629. (Correspondence)

11.Shan Liang, Zhiyang Liu, Shaoli Wang, Jing Liu, Ling Shi, Wei Mao, Cunxu Liu, Jianhua Wan, Lili Zhu, Mei Huang, Yu Liu, Jingxing Wang, Paul Ness, Hua Shan, Peibin Zeng , Miao He (2020) The genotype distribution, infection stage and drug resistance mutation profile of human immunodeficiency virus-1 among the infected blood donors from five Chinese blood centers, 2014–2017. PLoS ONE 15(12): e0243650. (Correspondence)

12.Yu Zhang, Zhan Gao, Shaoli Wang, Jing Liu, Ness Paul, Tao He, Cunxu Liu, Hongbin Zhang, Yunlai Lv, Ru’an Cao, Wei Mao, Jianhua Wan, Hongli Ma, Mei Huang, Yu Liu, Jingxing Wang, Pu Liao, Peibin Zeng, Miao He*, Hua Shan (2020) Hepatitis C virus genotype/subtype distribution and evolution among Chinese blood donors: Revealing recent viral expansion. PLoS ONE 15(7): e0235612. (Correspondence)

13.Peibin Zeng , Jing Liu, Chunhong Zhang, Bowei Zhang, Wei Liu, Mei Huang, Hongli Ma, Yuwei Zhao, Rong Guo, Miao He, Yu Liu, Dan Liao, Marian Sullivan, Jingxing Wang,Wei Cai, Paul Ness, Hua Shan (2020) Current risk factors for HIV infection among blood donors in seven Chinese regions. 2020 Feb;60(2):326-333. 

14.Ling Shi, Yu Liu, Jingxing Wang, Peibin Zeng, Zhan Gao, Shaoli Wang, Ping Fu, Jing Liu, Wei Mao, Weilan He, Hongli Ma, Mei Huang, Jianhua Wan, Dan Liao, Donald Brambilla, Marian Sullivan, Shimian Zou, Paul Ness, Miao He, Hua Shan, 2019 HIV Prevalence and Incidence Estimates Among Blood Donors in Five Regions in China. Transfusion 2020 Jan;60(1):117-125. PMID 31845344. (Correspondence)

15.Yonghua Yin, Kai He, Bingting Wu, Min Xu, Lianming Du, Wei Liu, Pu Liao, Yu Liu, Miao He, 2019 A systematic genotype and subgenotype re-ranking of hepatitis B virus under a novel classification standard. Heliyon. 2019 Oct 23;5(10):e02556. (Correspondence)

16.Ling Pu, Zuoyi Jian, Fen Pan, Yang Geng, Miao He, Pu Liao. Comparative genomic analysis and multi-drug resistance differences of Acinetobacter baumannii in Chongqing, China. Infect Drug Resist. 2019 Sep 11; 12: 2827-2838. doi: 10.2147/IDR.S216745. eCollection 2019. (Correspondence)

17.Zhan Gao  Jing Liu  Ping Fu  Mei Huang  Ru'an Cao  Xiuqiong Wen  Chunhong Zhang  Tao He  Wei Mao  Dan Liao  Ling Ke  Yashan Yang  Miao He*  Yu Liu  Jingxing Wang  Roger Y. Dodd  Paul Ness  Hua Shan Estimation of hepatitis B–positive rates in Chinese blood donors by combining predonation and postdonation screening results. Transfusion; 59(5):1749-1754. doi:10.1111/trf.15158 (Correspondence)

18.P. Zeng, Q. Liao, Z. Gao, M. He* & X. Rong Sero-prevalence and viremia status of dengue virus among asymptomatic blood donors post epidemic outbreak in Chinese Guangzhou in 2015, Transfusion Medicine, 2018 Dec;28(6):468-469. (Correspondence)

19.Min Xu, Yashan Yang, Ya Zhou, Zhiyang Liu, Yu Liu, and Miao He* 2017 Metagenomics in pooled plasma, with identification of potential emerging infectious pathogens. TRANSFUSION, 2018 Mar; 58(3):633-637. (Correspondence)

20.Z. Gao, Y. Zhang, Y. Yang, M. Xu,P. Liao, W. He, J. Xu, Y. Liu , M. He* 2018 Dengue virus infections among blood donors in Guangxi of China, 2013–2014. Transfusion Medicine, Jun;28(3):236-242. (Correspondence)

21.Zhan Gao, Yu Zhang, Hua Shan, Ling Shi, Jing Liu, Min Xu, Peibin Zeng, Yu Liu, and Miao He. A 30-year systematic review and meta-analysis of hepatitis B virus among blood donors in mainland China: revealing increase of new threats. TRANSFUSION 2017; 57; 1988–1997. (Correspondence)

22.Zhang Y, Chen LM, He M*. Hepatitis C Virus in mainland China with an emphasis on genotype and subtype distribution. Virology Journal (2017) 14:41. (Correspondence)

23.Zeng P, Liu Y, He M*, Wang J, Keating S, Mao W, et al. (2017) The infection staging and profile of genotypic distribution and drug resistance mutation among the human immunodeficiency virus-1 infected blood donors from five Chinese blood centers, 2012-2014. PLoS ONE 12(6): e0179328. (Correspondence)

24.He M*, et al, The Impact of Emerging Infectious Diseases on Chinese Blood Safety, Transfus Med Rev, 31 (2017) 94–101.

25.Wang M, Fu P, Yin Y, He M*, Liu Y. PLoS One. Acute, Recent and Past HEV Infection among Voluntary Blood Donors in China: A Systematic Review and Meta-Analysis. Plos One, 2016, 11 (9): e0161089. (Correspondence)

26.Yu Liu, Peibin Zeng, Jingxing Wang, Gui Liu, Min Xu, Ling Ke, Miao He* and Zhong Liu, 2014 Hepatitis B virus infection in a cohort of HIV infected blood donors and AIDS patients in Sichuan, China. J Transl Med. 2014 Jun 12;12:164. (Correspondence)

27.Y Liu, HL Ma, SH Chen, JX Wang, G Liu, M Xu, L Ke, and M He*, 2013, Interleukin-28B genetic variations and spontaneous clearance of hepatitis C antibody–positive blood donors in China. Transfusion. 53: 2498-2504. (Correspondence)

28.M He, J Zhu, L Ke, L Gao, ZH Pan, XH Yang, WP Li, HIV/Human parvovirus B19 co-infection in blood donors and clinical patients in Sichuan, China. Blood Transfusion, 2012; 10(4): 502-14.

29.L Ke, M He, CQ Li, Y Liu, L Gao, F Yao, J Li, XH Bi, YL Lv, JX Wang, ML Hirsch, WP Li, 2011, The prevalence of human parvovirus B19 DNA and antibodies in blood donors from four Chinese blood centers. Transfusion, 51: 1909-1918. (Equal contribution)